394: More than my marrow

Diversions. PubMed and me: Why my coughs are more productive than my searches.

Jaw bone marrow-derived osteoclast precursors internalize more bisphosphonate than long-bone marrow precursors.

Bisphosphonates (BPs) are widely used in the treatment of several bone diseases, such as osteoporosis and cancers that have metastasized to bone, by virtue of their ability to inhibit osteoclastic bone resorption. Previously, it was shown that osteoclasts present at different bone sites have different characteristics. We hypothesized that BPs could have distinct effects on different populations...

Dmd055897 394..406

An increased appreciation of the importance of transporter and enzyme interplay in drug clearance and a desire to delineate these mechanisms necessitates the utilization of models that contain a full complement of enzymes and transporters at physiologically relevant activities. Additionally, the development of drugs with longer half-lives requires in vitro systems with extended incubation times...

My complete works and more*

PREFACE As we approach our last quarter of a century, some of us who might by some extension of the word be called writers may be swept away by a desire to summarize. This is my shot at writing a summary. By what standard am I a writer? When I was a little boy in the East Bronx, people would point with great respect to rather ragged men, often with flapping overcoats and scarred shoes and usual...

My pack is cuter than your pack.

Faced with bans on advertising, the tobacco companies are looking to new, more subtle ways of maintaining their brands' profile in the public eye.